However, our results for the T557A mutant, which is defective in Plk1-binding and phosphorylation but does not show any localization defects, suggest that regulation of GCP-WD by Plk1 is not essential for spindle localization of γTuRCs.
Both OsPrxIIE2 and OsPrxQ were down-regulated in the dxr mutant, which is defective in the light response.
So far, the strongest phenotype reported for a single glr mutant is in rice which is defective in the OsGLR3.1 gene (Li et al. 2006).
We have compared this with the effect of expressing a mutant form which is defective in PCNA-binding, but which retains the secondary cyclin CDK-inhibitory site.
Thus it appears that PKC phosphorylates and regulates two different sites on the channel or on an associated membrane protein, one of which is defective in cystic fibrosis.
But soon after it was approved, Gleevec was found to inhibit another tyrosine kinase called c-kit, which is defective in people with a rare gastrointestinal tumor.
In the rice mutant 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), which is defective in the light response, downregulation of two PRX genes indicated the involvement of those proteins in DXR-mediated light signaling.
Increased ROS also damage the DNA mismatch repair system, which is defective in rheumatoid arthritis, and the DNA itself, resulting in elevated concentrations of 8-oxo-7-hydro-deoxyguanosine [78].
To determine whether rcn4 is involved in a branch-inhibiting strigolactone pathway, we characterized the double mutant of rcn4 and a tillering dwarf mutant, dwarf10 (d10), which is defective in strigolactone synthesis.
Stavropoulos treats Hart (and others) as having a semantic theory for the concept of a contract which is defective because it takes the content of the concept to be determined by shared beliefs or 'criteria'criteria
However, these experiments were performed in strain MG1655, which is defective in cell death [33].
