This mouse is widely used and carries a human mutant transgene array with a glycine to alanine mutation at residue 93 of SOD1, which is causative for ALS in humans, and which results in a similar phenotype in the mice who succumb to endstage disease at ∼130 d of age (depending on genetic background)[19].
Reduced caspase 8 expression levels were detected in SW948-TR as compared with SW948 (figure 1C), which is causative for the observed rhTRAIL resistance in these cells [ 33].
They obtained over 30 gigabyte (GB) DNA sequencing data and found a SNP in gene MYH3 straightforward, which is causative for a monogenic human disease called Freeman Sheldon syndrome (FSS).
Optimal in vitro CT expression in the El Tor biotype of V. cholerae serogroup O1 which is causative bacterium of ongoing 7th cholera pandemic had been persistently discussed because optimal condition for CT expression in El Tor biotype was significantly different from that for classical biotype which was responsible for the earlier cholera pandemics.
These species include, among others, Bacillus cereus, an important pathogenic species involved in food poisoning, and Bacillus licheniformis, Bacillus subtilis and Bacillus pumilus, which are causative agents of food spoilage described as responsible for foodborne disease outbreaks.
The study population will be stratified for those receiving concurrent treatment for RM, those with underlying medical conditions which are causative of RM, and number of previous miscarriages.
Similarly, FUS/TLS, dominant mutations of which are causative for familial ALS, is a protein possessing multiple functions including regulation in transcription and splicing (Lagier-Tourenne & Cleveland, 2009).
Strikingly, we report that an atypical strain of E. tarda has a pathogenicity island that is homologous to the pathogenicity islands of virulent Escherichia coli strains, which are causative agents of outbreaks of human foodborne illness.
The Trypanosoma brucei complex contains a number of subspecies with exceptionally variable life histories, including zoonotic subspecies, which are causative agents of human African trypanosomiasis (HAT) in sub-Saharan Africa.
Homozygous mutations in HOXA1 cause an early and profound brainstem patterning defect and heterozygous mutations in KIF21A, which are causative for congenital fibrosis of the extraocular muscles type 1, lead to disturbance of anterograde organelle transport in neuronal cells [ 2].
The clostridial neurotoxin family includes botulinum neurotoxins, serotypes A, B, E, and F of which can cause human botulism, and tetanus neurotoxin, which is the causative agent of tetanus.
