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Large, structured RNAs traverse folding landscapes in which intermediates and long-lived misfolded states are common.
We find that assembly pathways can be categorized into two classes, in which intermediates are either predominantly ordered or disordered.
Direct channeling is a well-known process in which intermediates are funneled between enzyme active sites through a physical tunnel and can be a potential way to enhance the biocatalytic efficiency for cascading bioreactions.
The pH of the system can rely on the rate at which intermediates are developed during fermentation (Chandra et al. 2012).
It has been proposed that the local concentration of dNTPs at the replication forks is higher than elsewhere in the cells and that this is achieved by a co-organization of nucleotide synthesizing enzymes and replication enzymes into structures in which intermediates are channeled from one enzyme to the next without diffusion of these intermediates into the surrounding cytoplasm [1], [2].
These effects gradually reduce the rate at which intermediates are produced, and make these intermediates effectively more deleterious relative to the mean fitness.
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In this paper we present a method in which intermediate 'precision' positions are described as distributions.
Between parental habitats was a zone in which intermediate hybrid genotypes survived at a higher rate than parental types; this zone is referred to as hybrid habitat.
The so-called hard α-keratins, such as quill and hair, have a composite structure in which intermediate filaments (IF) are embedded in a sulfur-rich matrix.
Another complicating factor is the fact that many reactions occur in stages in which intermediate products (intermediates) are formed and then converted by further reactions to the final products.
There has been much interest in the printing of silver inks onto flexible substrates, for which intermediate dielectric layers are often required to achieve suitable wettability.
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