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We evaluated antibody/inhibitor-mediated virus neutralization using either TZM-bl target cells, in which infectivity was determined by virus-driven luciferase expression, or A3R5 lymphoblastoid target cells, in which infectivity was evaluated by GFP expression.
The bacteriophage-encoded tubulin PhuZ is required to position DNA at mid-cell, without which infectivity is compromised.
BSE agent was also detected in skin, conjunctiva, and salivary gland, tissues in which infectivity has not previously been reported in any naturally occurring TSE.
We propose that the addition of SDS would have decreased aggregation of cell membranes to which infectivity is bound, thus enhancing the activity of SPC-P and perhaps contributing to the increased survival observed with the combination.
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By fitting an exponential, I x) = I0 – A exp[ x(F / x0], we obtained an empirical correlation between the infectivity, I x), and the force-dependent extensibility, x(F), in which CD4WT infectivity is considered an asymptote that represents maximum infectivity.
Of the models which allowed infectivity to vary on 23rd February, allowing only cattle infectivity variation gave a slightly better fit than varying sheep infectivity or both.
These difficulties generate a limitation for studying the functions of TuMV mutants, in which weaker infectivity may be incurred by mutations.
The neutralizing titer was defined as the reciprocal of the highest dilution of serum at which the infectivity of 100 TCID50 of H5N1 virus for MDCK cells was completely neutralized in 50% of the wells.
The neutralizing titer was defined as the reciprocal of the highest serum dilution at which the infectivity of the H5N1 virus' 200 TCID50 for MDCK cells was completely neutralized in 50% of the wells.
Behavioural factors which influence infectivity include condom use and needle exchange programs.
Efficacy analysis in this study refers to the efficiency at which 100% infectivity is conferred by each dosing regimen.
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