However, the "master copy" hypothesis, which generates highly imbalanced trees, can be statistically rejected for most families.
Our system is well-suited for measurement of such variation – we have profiled 7 animals of the same gender and similar age per time point from a genetically-homogeneous strain of mice using SMS, which generates highly reproducible results [ 17], a key to the endeavor.
Usually, corporate bonds, which generate highly taxed ordinary income, and actively managed funds, which pass through taxable gains to holders, belong in tax-deferred accounts.
Since the analytes, EDTA and DTPA, do not contain chromophores, transition metal ions (Cu2+, Fe3+) which generate highly stable metallocomplexes with the chelating agents were added into the sample preparation to enhance UV detection.
Two different H3 antibodies (each with two biological replicates) were utilized which generated highly reproducible results (Pearson correlation R = 0.82 across ∼2.6 millions probes).
However, the oxidation of the probe by ClO− perturbs a new equilibrium of the structural interconversion between the nonfluorescent spirolactone and the fluorescent ring-opened zwitterion, which generates a highly selective fluorescent probe for ClO−.
A key fluorogenic reaction used in FEEM is the reduction of resazurin (S), which generates a highly fluorescent product, resorufin (P).
Introduction of transgenes in worms is most often accomplished by gonadal injection of plasmid DNA, which generates a highly repetitive, nonintegrated (extrachromosomal) array of the injected DNA [ 75].
Mechanistically, captan and folpet induce toxicity by reacting with thiols in GSH and proteins, which generates the highly reactive thiophosgene that also interacts with thiols and other cellular constituents (Cohen et al., 2010).
We further applied live cell imaging using hydroxyl radical and peroxynitrite sensor hydroxyphenyl fluorescein (HPF), which generates a highly fluorescent oxidation product after reaction with peroxynitrite anions or hydroxyl radicals.
Whereas vertebrates use somatic rearrangement of immunological receptors to induce adaptive immune responses, one mechanism employed by the host defenses of invertebrates to confer adaptation to infection is alternative splicing of pattern recognition genes, such as Down syndrome cell adhesion molecule, which generates a highly diverse set of >31,000 potential alternative splice forms (10, 11).
