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In contrast to chemical mutagenesis (e.g. ethyl methanesulfonate EMS treatment) which generates frequent point mutations and small deletions, HII generates a relatively high frequency of large (whole gene) deletion mutations.
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In this case, the extraction is language-dependent, as the identification of the candidates requires the specification of some type of linguistic knowledge (for example: the syntactic category of the words) that is obtained by tools, such as taggers and parsers, lemmatizers, etc, which generate frequent errors that affect the tasks of identification and extraction of candidate terms.
Among Caucasians the most frequent inactivating polymorphism in CYP2D6 is the CYP2D6*4 allele, which generates a G → A transition at nucleotide 1934 leading to a disruption of the reading frame and to a truncated non-functional gene product [ 14].
Patients with IBS-D suffer markedly from loose and frequent stools, and particularly from the associated urgency and fear of incontinence which generates panic and anxiety.
The most frequent chromosomal rearrangement in ALK-positive DLBCL is the t(2 17)(p23 q23) translocation which generates CLTLC ALK, although a few cases of NPM ALK fusions have also been described [ 203, 204].
Large churches generate publicity, which generates conversations, which generates more opportunities to share Christ with friends and co-workers.
Go to a website which generates histograms.
Several factors can explain these findings; they had significantly more buccal surfaces with gingival recessions that indicate a persistent, intensive tooth brushing technique (possibly related to pervasive behaviours) and they also reported less frequent snacking, which generate lower levels of dental plaque.
The comparison of molecular structures and HTS data across many projects allows to identify and validate structural patterns of frequent hitters, i.e. compounds which generate multiple hits in various target families.
Interestingly, frequent missense and truncating mutations were observed, which generated some confusion in the field about whether EZH2 could possess both pro- and anti-oncogenic functions.
It is known that repetitive gene regions are prone to errors during replication which generate changes in the number of repeat units that are up to 10000 times more frequent than point mutations [ 51].
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