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When this occurs, it causes the sarcomere to shorten, which generates force.
Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
The Snf2 domain is thought to facilitate ATP-dependent translocation of Snf2 proteins along DNA, which generates force that can be channelled into the movement or destabilisation of nucleosomes (Cairns, 2007).
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Accurate chromosome segregation during eukaryotic cell division is achieved by a microtubule-based bipolar spindle which generates forces to move the replicated chromosomes toward opposite poles.
Movement of the cell occurs via the actomyosin motors which generate force.
In one model, the A-motility system functions similarly to junctional pore complexes in gliding cyanobacteria, which generate force by polyelectrolyte secretion (Hoiczyk and Baumeister, 1998; Wolgemuth et al, 2002).
T4P form bundles which generate forces in the nanonewton range [12].
It would be interesting to investigate how the dynamic assembly and disassembly of microtubules, which generate forces in other systems (reviewed in Dogterom et al., 2005), contribute to the properties of this network.
Thus the trabecular pattern of the femur is arranged to withstand loading from above and not to withstand a blow on the greater trochanter from the side, as occurs in falls in the elderly and which generates a force that greatly exceeds the strength of any hip [ 11].
The most familiar motor protein is myosin, which generates the force responsible for muscle contraction.
For example, mutations in α-cardiac actin cause hypertrophic cardiomyopathy when they affect actin-myosin interaction (which generates the force of contraction), but cause dilated cardiomyopathy when they affect interactions between actin thin filaments and myocellular proteins outside the sarcomere (which generate transmission of force) (Olson et al., 1998).
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