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We then distinguish between: (i) targeted operators, which restrict the mutational space to specific regions of the sequence that are therefore more likely to affect the property that needs to be evolved; and (ii) oriented operators, which further specify particular mutation patterns to bias the production of variants toward the current design target.
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Sub1 was mapped to a 0.16-cM region with circa 3,000 F2 progeny on 9th Chromosome [ 80] and using 4,022 F2 individuals a fine-scale physical mapping of Sub1 also done, which further specified the position of locus 0.075 cM [ 69] using two different types of varieties, the resistant indica Teqing and tolerant FR13A derivative IR40931-26.
(Both of which further define your character!).
In an initial global gene expression analysis of the UkrAm cases a set of 11 genes with dose-dependent expression has been observed (15) which was further specified in a second study revealing eight genes in normal tissues and six genes in tumor tissues that were significantly associated with I-131 dose (16).
His contemporary, Vernon (1950, p. 47), included an "X" factor along with a cognitive Spearman-type g factor in his model of the structure of "educational abilities", under which, among other things, he subsumed personality and interests (although he did not further specify which non-cognitive factors he deemed crucial).
But if "the people" does not, and cannot, mean all people, and if the Founders did not further specify which people -- then that is a question we are obligated to ask and answer.
To further specify which domains of MKS1 are important for these interactions, we performed a directed yeast two-hybrid analysis with two N-terminal deletions and three C-terminal deletions (Figure 4).
To further specify which connections drive differences in the HCR, the lobar connectivity weight (LCW) was computed.
These recommendations add to, and further specify, those which we have previously made in the BMJ.
Bolyai excised the postulate from Euclid's system; the remaining rump is the "absolute geometry", which can be further specified by adding to it either Euclid's Postulate or its negation.
To illustrate: at the constitutional and legislative stages the parties specify abstract basic liberties such as "freedom of thought" into more particular rights like the right to free political speech, which is then further specified as the right to criticize the government, the special rights of the press, and so on.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com