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The aging process significantly lowers the moisture erosion resistance ability, which further impairs the water damage resistance ability.
This inactivation is due to its promoter methylation, which further impairs its response to environmental stresses.
Duodenal resection leads to significant maldigestion of nutrients which further impairs the intestinal absorption.
Furthermore, pH >7.40 increases the affinity of haemoglobin for oxygen and may cause hypoxaemia, which further impairs cardiac function.
They are also more likely to have been worried or upset about their oral health status, which further impairs their quality of life [ 28, 29].
These cellular and molecular changes greatly influence the progression of IDD, which further impairs the biological and mechanical function of the intervertebral disc and patients' quality of life.
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Worries about tapering this summer caused capital flight from places like India, which further impaired growth (and nudged up interest rates) and pushed its fiscal deficit up to a forecast 8.5% for the 2013/14 fiscal year.Even countries that have looked prosperous over the last few years now seem a bit less healthy.
Some authors advocate dose reductions in CKD patients, but this can be dangerous because declines in the GFR can always happen with incident fluid losses - for example, through vomiting, diarrhea, use of diuretics or NSAIDs, sweating or fever - which further impair methotrexate clearance without a physician even being consulted.
Macrolides are also inhibitors of P-glycoproteins which can further impair colchicine elimination which is well reported [ 5– 7].
The significant correlation between the GPC predictive probabilities and ADHD symptom severity suggests that the most severely impaired ADHD patients are more confidently predicted by their immature fronto-limbic activation patterns than the less severely impaired ones, which further reinforces the potential diagnostic value of GPC pattern recognition analyses combined with fMRI for ADHD.
GBA mutations impair lysosomal function, leading to α-synuclein accumulation, which further decreases lysosomal GBA activity by impairing the trafficking of GBA from the endoplasmic reticulum-Golgi to lysosomes, leading to neurodegeneration [ 77].
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