The aging process significantly lowers the moisture erosion resistance ability, which further impairs the water damage resistance ability.
This inactivation is due to its promoter methylation, which further impairs its response to environmental stresses.
Duodenal resection leads to significant maldigestion of nutrients which further impairs the intestinal absorption.
Furthermore, pH >7.40 increases the affinity of haemoglobin for oxygen and may cause hypoxaemia, which further impairs cardiac function.
They are also more likely to have been worried or upset about their oral health status, which further impairs their quality of life [ 28, 29].
The children with low CD4 count at initiation could have an increased risk of opportunistic infections which further impairs the positive effects of the ART.
It is likely that mitochondrial iron overload contributes significantly to disease progression by oxidatively damaging the mitochondria, which further impairs function.
These cellular and molecular changes greatly influence the progression of IDD, which further impairs the biological and mechanical function of the intervertebral disc and patients' quality of life.
Ischemia induces a decline in the levels of LAMP2, a protein critical for autophagosome lysosome fusion, mediated by ROS-induced activation of serine and cysteine proteases; reperfusion induces upregulation of Beclin 1, which further impairs autophagosome processing, culminating in increased ROS generation, mitochondrial permeabilization, and cardiomyocyte death.
Some authors advocate dose reductions in CKD patients, but this can be dangerous because declines in the GFR can always happen with incident fluid losses - for example, through vomiting, diarrhea, use of diuretics or NSAIDs, sweating or fever - which further impair methotrexate clearance without a physician even being consulted.
