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The pathophysiological alterations precipitating this condition include dynamic hyperinflation and expiratory flow limitation as a result of respiratory muscle fatigue, which further aggravates respiratory acidosis.
The catchment area under greater agricultural activities is subjected to huge quantities of fertilizers which after their partial utilization get leached into the lake waters, thus leading to the nutrient enrichment and eutrophication which further aggravates the growth of microorganisms.
Second, increased ATP consumption causes a breakdown in mitochondrial membrane potential leading to calcium accumulation [16], which further aggravates mitochondrial dysfunction.
Inflammation leads to insulin resistance (14) and β-cell dysfunction, which further aggravates hyperglycemia.
Moreover, recent evidence suggests that FGF-23 may contribute to volume retention, which further aggravates CS [ 33].
The ensuing decreased NO bioavailability, also increases vascular smooth muscle cell tone, which further aggravates arterial stiffness [ 11].
Similar(49)
The cold temperature continued, which further aggravated the extent of damage.
The neoliberal approach allowed chaebols to expand which further aggravated their debt-to-equity ratios owing to increasing demand for capital, majority of which was borrowed from abroad.
Due to Hodgson's misdiagnosis, which was not corrected until a year later, subsequent treatment and rehabilitation was designed for a bulging disc, which further aggravated his real injury – a muscle strain.
Reduced UUAE led to impaired renal function, which further aggravated the decreases in UUAE.
Further studies showed that under nutrient deprivation, autophagy inhibition promoted mitochondrial ROS generation, which further aggravated mitochondria damage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com