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Furthermore, we predicted 260 gene fusions which frequently result in aberrant over-expression of the 3′ genes in tumors and validated 18 gene fusions, including recurrent fusion (2/88) of ABCB11 and LRP2.
Conversely, new questions lead to new research strategies, new categories of analysis, and an expanded repertoire of explanatory hypotheses, which frequently result in research programs that chart new domains of inquiry (see the section From Selective Appropriation to Content Critique).
Alternative ways are to use housekeeping genes, the largest possible DNA region or concatenation of core genes, which frequently result in biased inference and systematic overestimation within-species [13], [14], [15].
Doubts have also arisen concerning species identification and delimitation based on single-locus DNA sequences, which frequently result in problematic under- or overestimation of species [ 16- 18].
Perioperative lactate levels, which frequently result from circulatory compromise, have been linked to clinical outcome in numerous surgical procedures [ 16– 16].
However, standard extraction mechanisms such as cell maceration and soxhlet extraction have limitations such as high solvent consumption, large operating cost and extended operation times which frequently result in lower yields [ 44].
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Rather than open defiance – which frequently resulted in David being whipped – the two found other ways to subvert their mother's rules.
At the cell surface DNA must undergo internalisation across the cell membrane, which frequently results in endosomal entrapment.
No solvent/additive combination produced solvent wetting conditions, though dodecylamine and octadecylamine significantly reduced the water wetting preference of sandstone which frequently resulted in neutral wetting conditions.
These components are subject to displacement loading which frequently results in cyclic strains well beyond the proportional limit for the material.
Vesicular trafficking is critical for the function of bone cells, exemplified by bone diseases such as osteopetrosis, which frequently results from defects in this process.
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