For the 41 genes for which favorable disease resistance effects could be produced in transgenic rice (Table 1 and ESM, Supplemental Table 2), 90% were found in blast QTLs.
Factors influencing the photodegradation process were investigated, including pH, humic acid, Fe2+, Ca2+, HCO3−, and NO3−, of which favorable conditions were optimized by the orthogonal array design under simulated sunlight irradiation in the presence of dissolved oxygen.
Further studies have to test whether dried high-WSC grass has the same effect when the WSC replace fiber and to address the extent to which favorable effects can be recovered in mixed forage-concentrate diets.
Among the most robust conclusions from these studies is that epistasis between beneficial mutations often shows a pattern of diminishing returns, in which favorable mutations are less fit when combined than would be expected.
The promising animal experiments led to clinical studies in patients with advanced solid tumors in which favorable responses were observed [ 47].
The only exception is the relatively infrequent type of medullary carcinoma, in which favorable prognosis was correlated with intensive lymphoid infiltration [ 1, 2].
