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K8/K18 variants may also affect organelle function, as seen in K8 knockout mice, which exhibit altered mitochondrial shape, localization, and alterations in several mitochondrial proteins (Toivola et al. 2005).
In this study, we sought to obtain variants of Kex2, a yeast Golgi protease, which exhibit altered P2 specificity.
By using an improved genetic screening system, variants of the HAV 3CP protease which exhibit altered P2 specificity were obtained.
It has been established that in diploid cells which exhibit altered MAT expression patterns, sensitivity to DSB damage is increased due to a decrease in recombination capability [51] [53].
Finally, the fourth cluster includes 13 genes which exhibit altered dynamics in Δ VNG0258H.
Taken together, hMSC represent a heterogeneous population of stromal/stem cells originating from perivascular niches of nearly all tissues which exhibit altered proliferation and differentiation capacities, and provide distinct levels of immune-modulatory activities [ 92].
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Using dopamine as a modulator of SNCA expression, we searched for a CpG island which exhibited altered methylation which correlated with changes in gene expression.
Sixteen genes were identified which exhibited altered expression at all three doses (Table 3).
OA, the most common form of rheumatic disease, is characterized by degeneration of articular cartilage, synovitis and changes to subchondral bone which exhibits altered remodelling [ 3, 4].
In addition, for many genes more than one methylation site was examined, some of which exhibited altered expression while others did not.
This property appears to be related to the association of versican with hyaluronic acid, which exhibits altered expression in neoplastic conditions [ 26].
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