MAO-B elevation alone was found to result in ∼60% reduction in striatal dopamine levels (Figure 1E) which was exacerbated further by MPTP.
27 Tissue trauma as a result of surgery also contributes to a profound inflammatory response near the surgical site, elevating cellular mediators, or cytokines, which further exacerbate inflammation and suppress the immune response.
Children of parents with depression may also learn maladaptive coping strategies such as attributing failure to personal, inherent characteristics, and ruminating over difficulties, which further exacerbate the ways in which they deal with the stress associated with their parents' depression [ 15].
Being young and depressed can leave you not wanting to get out of bed in the morning, which further exacerbates depression and vice versa.
Correspondingly, loss of Sesn2 allows for persistent protein synthesis in hepatocytes even under chronic ER stress, which further exacerbates the level of ER stress and subsequently results in extensive NASH-like pathologies such as liver damage, inflammation and fibrosis.
Nor was there sufficient access to information, which further exacerbated uncertainty regarding preparedness, response and mitigation decision-making.
Also, overlying rock unloading results in fault development, early fault activation, and expansion, which further exacerbates destroy of oil and gas reservoir in Dingshan block of southeastern Sichuan, China.
Except for empirical studies that reveal health inequality, equitable healthcare service has not been put into effect in practice, which further exacerbates outcome inequity for vulnerable older people.
Intense soil erosion also contributes to have farmlands with poor soil fertility level, which further exacerbates the vulnerability levels of households in terms of farmland.
In addition, selecting a low detection threshold leads to a high FAP, which further exacerbates the reduction of available resources for the SUs.
