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The results indicate that the mechanism of transcription inhibition by Sal differs from the mechanism of transcription inhibition by Rif, which does not inhibit the first nucleotide-addition step in transcription initiation.
The presence of the N-terminal Ala-Ser may also be a contributing factor to the inhibition of velocity by AS-Tmsta in contrast to Tm2, which does not inhibit, with skeletal myosin.
The tetrapeptide Arg-Gly-Glu-Ser, which does not inhibit fibrinogen binding, did not inhibit thrombin-stimulated tyrosine phosphorylation.
A third drug, which does not inhibit LRRK2, was not effective.
Swapping domains between AtEHD2 and AtEHD1 (which does not inhibit LeEix2 endocytosis and signaling) leads to similar findings.
The effects of the RXPO3R, which does not inhibit ADAMs [23], argues against a significant implication of these metalloproteinases as mediators of TIMP-1 effects on cortical neurons.
Similar(30)
Cytosine β-D-arabinofuranoside hydrochloride (Sigma) (10 µM), a selective inhibitor of DNA synthesis which doesn't inhibit RNA synthesis was used 1 h before the test substance was added.
The results confirm that the mechanism of transcription inhibition by Sal differs from the mechanisms of transcription inhibition by Rif, Myx, and Lpm, which do not inhibit transcription elongation.
The ester prodrugs (12a c, 14a c), which did not inhibit the COX-1 isozyme, exhibited modest inhibitory activity against the COX-2 isozyme.
An optimized compound which did not inhibit CYP2C9 exhibited potent anti-NAMPT activity (17; BC NAMPT IC50 = 3 nM; A2780 antiproliferative IC50 = 70 nM), good mouse PK properties, and was efficacious in an A2780 mouse xenograft model.
At concentrations which do not inhibit mitochondrial function, Rhodamine 123 is a sensitive and specific probe of delta psi in isolated mitochondria.
More suggestions(15)
which does not conform
which does not use
which does not imply
which does not have
which does not appear
which does not participate
which does not fly
which does not immunize
which does not depend
which does not approach
which does not mean
which does not alter
which does not confirm
which does not include
which does not change
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