Second, although participants were selected based on some established cognitive measures, they were relative healthy and physically mobile, which could explain the relatively small effect observed.
We also found that Aβ peptide with Icelandic mutation A673T affects axonal trafficking of mitochondria but has very low rates of plasma membrane binding and internalization in neurons, which could explain its relatively low toxicity.
Second, we included cases only from an outpatient setting to form the MDD group, which could explain the relatively small number of patients with severe treatment resistance; thus, the results are not necessarily representative of the larger population of patients with MDD.
Most patients (80.2%) were receiving analgesics which could explain the relatively low pain scores (overall mean 3.2/10).
In that study, optometrists had received special training in the identification and grading of DR, which could explain the relatively high sensitivity levels observed.
These discrepancies might lead to higher irritability or nervousness in girls, which could explain the relatively stronger association with a lower frequency of these health complaints in boys.
It is possible that there is a partial redundancy between DS and HS in these signaling pathways, which could explain the relatively low penetrance of these phenotypes.
Therefore, the group of patients could probably be considered a survival cohort, which could explain the relatively mild level of functional disability as compared to other cohorts of patients with SSc [ 10, 13].
Accordingly, absence of βb use may have been confounded by the presence of other diseases like asthma, which could explain the relatively lower degree of perinatal morbidity with βb therapy compared to non-βb treatments.
Apparently, Mo milk concentrations decrease with the stage of lactation [ 6], which could explain the relatively high concentrations of Mo found in the present study compared to 1989 data (median 0.40 μg Mo/L).
