The objective was to gain a deeper understanding about the types of the questions which are asked naturally and whether they could be reformulated in a structured PICO framework.
As concerns the impact of the obligate intracellular group, the question could be reformulated as the reactions which could not be dispensed and/or outsourced to the host in the course of genome compaction.
Note that if there is no information leakage constraints, i.e., (9c), problem (9) could be reformulated as a convex second-order cone program (SOCP), which can be efficiently solved [29].
But what if the design of small cars could be reformulated to transcend their size?
As a future work, the optimization problem could be reformulated for systems with multiple antenna and variable transmission rates.
The sentence " There are many cases in which a DNA mutation cannot be mapped to a protein mutation and frameshift mutations like L280FfsX4 are not covered by SETH " on page 13 is (in my opinion) confusing and could be reformulated.
They could be reformulated for oral dosage (tablets, capsules and pills) that might provide better control of drug release rate.
Indeed, it does not even make specific predictions that can be compared with data (although it could be reformulated to do so in certain cases).
Further complicating the issue is that the two companies are working a reformulated version of Byetta, which could be injected once weekly instead of twice daily, and they may prefer to run the trial on the new medicine, which has not yet been approved by the Food and Drug Administration.
The problem is firstly formulated as a minimax problem, and then reformulated as a semidefinite programming (SDP) problem, which could be solved by many interior-point algorithms.
Which could be all for the better.
