Sentence examples for which consecutively leads from inspiring English sources
This pathway appears to be significantly downregulated by low FXR levels, which consecutively leads to low LKB1 levels as observed in patients suffering from severe liver fibrosis.
This effect was hypothesized to be caused by water efflux through aquaporin-1 channels of the microvascular endothelium, which consecutively leads to NO release by the endothelial cells [ 31, 32].
Lithocholic acid appears to induce the translocation of VDR from the cytosol to both the nucleus and the cellular membrane, which consecutively leads to the heterodimerization of VDR with RXRα, the recruitment of co-repressors and the final inhibition of CYP7A1 gene transcription (Han and Chiang 2009).
Moreover, the hepatic segment of the inferior vena cava (IVC) was compressed by the hepatic tumors, which consecutively led to a partial Budd Chiari syndrome.
He developed a multiresistant Pseudomonas aeruginosa infection of the allograft which led to a prolonged intensive care therapy with septic shock and pneumonia which consecutively led to death [ 45].
In this context, mutant desmin may exert a pathogenic effect on the viscoelastic properties of the desmin filament system, which consecutively may lead to progressive muscle fiber damage and muscle weakness.
As PDRICG is dependent from both hepatocellular function and effective sinusoidal perfusion, this consecutively leads to reduced PDRICG.
This mechanism consecutively leads to a suppression of CYP24 expression, one of the important enzymes involved in vitamin D3 degradation (Mohri et al. 2009).
Progression of the SWR1-mediated reaction on the canonical 'AA' nucleosome generates the 'AZ' and 'ZZ' nucleosome states consecutively, which leads to repression of the ATPase and histone exchange activities of SWR1 by the H2A.Z-nucleosome end-product, thereby preventing futile expenditure of chemical energy (Luk et al., 2010).
Oxidative stress caused by nicotine or ethanol could lead to the peroxidation of the lipid bilayer of the cell membrane, which consecutively disintegrates the membrane [ 11].
This limitation was overcome by using NR as a binder which consecutively rendered elasticity and strength of the films.
