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Despite intense research efforts, there currently remains no NOX4-specific inhibitor and several attempts to generate peptides that disrupt NOX4 function have been unsuccessful with the authors concluding that, unlike other NOX isoforms, NOX4 exists in a tightly assembled and active conformation, which cannot be disrupted by conventional means [ 142, 143].
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Our data also suggest that VANGL2 asymmetry cannot be disrupted by abolishing autocrine WNT signaling.
These dimers cannot be disrupted even when diluting the protein to concentrations as low as 20 nM.
We now show that the genes encoding both regulatory PfCK2 subunits (PfCK2β1 and PfCK2β2) cannot be disrupted.
"Tourism provides jobs which cannot be exported".
The stream creates a different form of syndication which cannot be licensed and cannot be controlled.
They profile them in a way which cannot be contested.
An observation, which cannot be entirely explained.
They usually have some function, which could be disrupted by a drug.
The benzyl groups form packed hydrophobic interactions in water, which can be disrupted mechanically during sonication.
There is a right to worship, which has been disrupted.
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