Failure to make changes will provide a planet which can no longer support our civilisation.
It is a way of doing business which can no longer be ignored.
Turkey's regional rival, Iran, is a key player which can no longer be ignored by the West.
The farmers must then return to pick up the meat, which can no longer be certified organic.
Another is a sectoral crisis; rising debt levels fueled growth in economic sectors which can no longer be sustained.
Analysts say Germans and other European consumers may be worried about changes in state pension systems, which can no longer afford the comfortable payouts of the past.
Lord Patten has spent his professional life working for institutions which can no longer command the deference they thought of as their right.
Accepting the urgency, it seems clear to me also that climate change is a problem which can no longer be left to a future generation," he said.
This new atmosphere poses a challenge for the automakers, which can no longer draw from their experience of the past to predict the future.
The triumph of porn has come at a cost to the industry itself, which can no longer produce a Jenna Jameson.
"We also need to invest in finding new markets for species that traditionally had no value," but which can no longer be discarded under the new rules.
