Because both activated macrophages and endothelial cells can express high levels of integrin, especially αVβ3 integrin, αVβ3 expression represents a combined marker of inflammation and angiogenesis, which are both implicated in plaque vulnerability.
Nol9 contains Walker A and a Walker B motifs which are both implicated in ATP/GTP binding (Walker et al, 1982).
One less well understood risk factor is stress, which could plausibly lead to COPD exacerbations as it can trigger inflammation [ 3], [ 4] and is associated with increased smoking [ 5], which are both implicated in COPD pathology [ 2].
Since PCI is present at high molar excess in seminal plasma, roughly 30% of total KLK2 and to a lower extent KLK3 are complexed with PCI, which are both implicated in the fertilization process [193 195].
As TH2 cytokines have been associated with tissue responses like wound healing and fibrosis, which are both implicated in tumorigenesis, it is reasonable to assume that TH2 cytokines may have an impact on skin tumor development.
BMP receptors signal through two different downstream pathways: the canonical signaling pathway through Smad1/5/8, and the non-canonical pathway through TAK1/TAB and p38 MAPK (Fig. 1A, reviewed by Nohe et al., 2004; Eivers et al., 2008), which are both implicated in the regulation of neural induction (von Bubnoff and Cho, 2001).
Oxidative stress enhances lipid peroxidation (LPO), which both are implicated in the promotion and progression stages of carcinogenesis, in particular under conditions of chronic inflammation and infections.
Oxidative stress enhances lipid peroxidation (LPO), which both are implicated in the promotion and progression of chronic degenerative diseases (CDD), including carcinogenesis, in particular under conditions of chronic inflammation [ 1].
In men, other factors may weigh more heavily than androgen status for the emergence of cardiovascular disorders, such as cholesterol [ 85] and alterations to the HPA axis [ 84], which both are implicated in depressive disorders [ 108, 109].
All it means is that someone said one name that sounds a lot like another name, in a conversation in which both names were implicated.
