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The link between determining binding specificity and finding sites where the transcription factor is likely to bind is the way in which binding specificity is represented.
However because there are many receptors that PfEMP1 can bind to it has been unclear which binding preference might be implicated in severe disease, particularly CM.
In fact, cohesin binds to the rDNA regions in every eukaryotic genome in which binding has been examined.
He expanded game theory to include cooperative games (in which binding agreements can be made) and non-cooperative games (in which they cannot), and to allow for the possibility of mutual gain.
However, there were only a small portion (less than 2%) of natural products which binding data has been reported [5].
Another challenge associated with the "bifunctional heterodimer concept" is which binding unit actually contributes to the radiotracer tumor uptake.
Moreover, molecular dynamics simulations have identified an allosteric mechanism by which binding of palinurin leads to GSK-3β inhibition.
Physical adsorption is a process in which binding of adsorbate on the adsorbent surface is caused by van der Waals forces of attraction. .
This may be useful when the property of interest is related to a biochemical process in which binding plays a key rôle.
We describe a new serine protease inhibition motif in which binding is mediated by a cluster of very short hydrogen bonds (<2.3 Å) at the active site.
Protein protein interface structures can also indicate which binding partners can interact simultaneously and which are competitive, and can help forecasting potentially harmful drug side effects.
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CEO of Professional Science Editing for Scientists @ prosciediting.com