Yet the political realism of a major power like Russia may lead it to abandon its losing wager and to stop making concessions, some of the assets of which have perhaps become ineffective.
Cutaneous malignant melanoma (MM) is a deadly cancer of melanocyte origin, for which conventional therapies become ineffective once the tumor metastasizes [ 9].
An additional challenge in the management of neonatal sepsis in most developing countries is a reliance on empirical use of antibiotics based on a recommended list of antibiotics, which are increasingly become ineffective owing to growing antimicrobial resistance [ 15- 18].
Understanding and accommodating the behavior of nitrogen utilization in microalgae is key to avoiding 'culture crash' and reliance on gas phase CO2 buffering, which becomes both ineffective and cost-prohibitive for commercial-scale algal culture.
Genetic variance steadily decreased over the next generations of selection, except in the pedigree BLUP selection method, which became rather ineffective after a few generations, therefore limiting the loss of genetic variance, even though the inbreeding rate was high for this approach.
Since the degree of decomposition at which FAT starts to become ineffective is unknown (4 ), when smears from decomposed samples are made for FAT, a suspension of the same brain tissues should be made in the appropriate diluents for the mouse inoculation test (MIT), cell culture, or reverse transcription polymerase chain reaction (RT-PCR) (2 ).
When excluding the WD repeat sequences, RIP inactivated NWDp1 and NWDp2 pseudogene sequences are about 80% identical, corresponding to the threshold level beyond which RIP is believed to become ineffective [26].
In addition, L-DOPA treatment, which should counteract decreases in dopamine, tends to become ineffective after a while, again demonstrating the complexity of the controlled, adaptive metabolic system.
If antibiotics become ineffective, then established and newly emerging infectious diseases, which are becoming an increasing threat, may lead to increased morbidity, health care utilisation and premature mortality [ 2- 4].
Clustering and ad hoc routing becomes more effective as the road conditions become more congested, which are the conditions where traditional WiMAX routing is demonstrated to become ineffective.
