To avoid rejection, we inoculated the cells into SCID (Severe Combined Immuno-Deficiency) mice, which are deficient in T and B cells.
Previously we have used a well-established technique to detect respiratory chain deficiency due to mtDNA mutations: the identification of cells which are deficient in COX but have normal succinate dehydrogenase (SDH) activity (Old and Johnson, 1989).
The hypothesis was tested by analyzing early passage fibroblasts from severe combined immunodeficient mice, which are deficient in DNA-PK.
Much of the data accumulated to date uses NIH 3T3 cells, which are deficient in the tumor suppressor gene p16, as models for these studies.
With attempted active motion, the humeral head moves superiorly and anteriorly unopposed by the rotator cuff or the coracoacromial arch, both of which are deficient.
In the second study, we found that Runx1P1N/P1N mice, which are deficient in the transcription factor distal promoter-derived Runx1 (P1-Runx1), have a marked reduction in the numbers of basophils in the bone marrow, spleen and blood.
Theory suggests that stars with initial masses greater than 25 30 solar masses end up as Wolf-Rayet stars, which are deficient in hydrogen in their outer layers; subsequent supernova explosions should produce ejecta of low kinetic energy, a faint optical luminosity and a small mass fraction of radioactive nickel, but no weak, hydrogen-deficient, core-collapse supernovae have hitherto been see.
In the next experiment, the authors set out to better understand the exact role of the iNKT cells by examining two strains of mice, both of which are deficient in iNKT cells, and a group of control mice, all on a high-fat diet.
Meteorites, comets and asteroids bring in water and many volatile elements (including rare gases) which are deficient on the Moon.
To do that, researchers would need to know which factors in the marrow matter most for repair and which are deficient after a heart attack.
We have studied the prenuclear signal transduction pathway by which thyroid hormone potentiates the antiviral activity of human interferon-gamma (IFN-gamma) in HeLa cells, which are deficient in thyroid hormone receptor (TR).
