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Seasonal affective disorder is characterized by the onset of depressive symptoms in autumn and winter, which are alleviated with increased exposure to natural light in spring and summer.
In aged subjects, the naturally occurring hypoactivity of the retinoid signaling pathway also induces spatial memory and hippocampal long term potentiation deficits, which are alleviated by the normalization of brain retinoid signaling with RA treatment or nutritional vitamin A supplementation [20], [21].
Symptoms which are alleviated by simple treatments are common.
For example do NOMPC mutants have changes in PDF Ca2+ signals, which are alleviated by NOMPC rescue in ASN?
Screen-detected, apparently asymptomatic older celiac disease patients may suffer from subclinical malabsorption, gastrointestinal symptoms or bone disease, which are alleviated during gluten-free dietary treatment.
Naïve T cells activated in the presence of IL-6 and TGF-β differentiate to Th17 cells to drive experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis, both of which are alleviated in IL-6−/− mice (reviewed in [ 9]).
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Diabetic myocytes exhibited enhanced levels of reactive oxygen species and apoptosis, which were alleviated by catalase.
Lectin staining displayed that diabetes promoted cardiac hypertrophy, the effect of which was alleviated by ALDH2.
Abnormal cerebellar input to VIM is presumed to be a major contributor to tremor symptoms, which is alleviated by DBS.
The ratio of liver to body weight was increased by chronic-binge ethanol exposure as compared with pair-fed group, which was alleviated by AXT administration (Fig. 1C).
The hypothesis that increase in dietary phytin amplifies phytin binding to protein thereby reducing protein digestion, which is alleviated by phytase, was tested.
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