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Alterations at 16q are much more frequent in low-grade DCIS than in high-grade DCIS, in which alterations at 13q, 17q, and 20q are more frequent [ 4, 6, 7, 10].
In addition, efforts should be made to better understand which alterations at the level of β-cell microenvironment are present and may impede the complete success of therapeutic interventions.
A recent example comes from the potassium channel subunit Kv7.2, encoded by KCNQ2, in which alterations at the same amino acid (p.Arg213Trp and p.Arg213Gln) lead to strikingly different phenotypes [ 69].
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Whether there is a potential argument to be made for a critical temperature or rate of change at which alterations in the oxidative/antioxidant balance occur, relies on future research.
Nonsense changes account for 21 of the 277 distinct gene alterations (8%) in GALNS reported from patients with Morquio A. Next, we examined the frequency at which alterations in the GALNS gene were reported from patients with Morquio A and totaled all reports of the same GALNS allele (Supp. Table S3, Fig. 2B).
Metabolomics represents a robust approach through which alterations in diverse metabolic pathways may be determined at a biological systems level.
It is not still elucidated, however, which mucin alterations at which stage of malignant transformation take place or become detectable [ 17].
The most sensitive endpoint was the colloid, which showed alterations at ≥250 μg/L.
Everyone loves Shakespeare, but love is not love which alters when it alteration finds.
"Love is not love," Shakespeare wrote, "which alters when it alteration finds".
This study was aimed at evaluating the effects of nascent obesity on the cardiac function of animals fed a high-fat diet and at analyzing the mechanisms by which these alterations occurred at the level of coronary reserve.
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