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The number of tested SNPs for which adjustment needs to be made represents those SNPs that have data available in both the Mayo tier 2 and NINDS datasets.
The number of tested SNPs for which adjustment needs to be made in the enhanced first-stage data is the common SNPs in both Mayo tier 1 and NINDS datasets; in the replication sample (Mayo tier 2), it is those SNPs that have p<0.05 at least by fixed effects in the combined Mayo tier 1 and NINDS datasets and have also been assessed in the Mayo tier 2 dataset.
An unadjusted estimate was preferred for each as prior knowledge indicated that adjusted results were likely to be highly inconsistent in the factors for which adjustment was made (Altman, 2001, pp 228 247).
In the logistic regression in which adjustment was made for the effects of pathogens, age and the administration of H2 receptor antagonists, late-onset VAP remained significantly associated with mortality (risk ratio=6.0, 95% CI =1.1 to 33.9; P=0.042).
Which adjustment?
The variable-focus, or zoom, lens was originally developed for motion-picture photography, in which adjustment of the focal length during a shot produced a zooming-in or zooming-out effect (hence the name).
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