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Most of the approaches for achieving antibacterial surfaces are based on doping some elements with silver particles which act as silver ion source, for example, in textiles [11, 12], surgical instruments [13], and other surfaces [14].

For example, RNAi knockdown studies have now identified many genes which act as antagonists of parasite development, and also genes that act as agonists protecting the parasite from mosquito immune responses [ 14].

For example, some β-defensins are chemoattractants for monocytes, lymphocytes and dendritic cells, which act as a link between innate and adaptive immune responses [25], [26], [27].

For example, critical roles of activated NF-κB, phospho-NF-κB and STAT3, which act as nonclassical oncogenes in CRC and other cancers have been reported [ 9].

a indicates PBS pH 7.4 which act as negative control.

Thus, it produces antioxidants which act as scavenger of ROS.

The single example proof of concept at CTLA4 (now Figure 5A) demonstrates that a cluster of disease-associated polymorphisms are found in Treg lineage-specific enhancers, which acts as both an example and as proof of concept that if the polymorphisms in this cluster are functionally altering disease course, than they most likely do so through differential Treg cell function.

The usefulness and effectiveness of the proposed procedure beside the optimal approximation and sensitivity analysis on main parameters is demonstrated using a numerical example which acts as a modification of Lin et al. (2009).

Methionine can be activated to S-adenosylmethionine, which acts as a methyl group donor, for example, for CNS myelination.

For example REB1, which acts as an enhancer under three cultivation parameters, is a RNA polymerase I enhancer binding protein as well as an activator for many genes transcribed by RNA polymerase II (Ju et al., 1990).

For example, senescent keratinocytes oversecrete maspin, which acts as a dominant inhibitor of endothelial cell migration and invasion [ 126].

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