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The conserved Asp95 in Box B of Tob is equivalent to Asp105 of BTG2, which abrogates the interaction with CNOT7 (Yang et al., 2008).
Conversely, smg-2 RNAi, which abrogates NMD, restores GFP expression [24].
Constant light, which abrogates clock function, depressed rhythms in both enzyme activity and rhythms in susceptibility to propoxur.
To test IDO functions we used 1-methyltryptophan (1-MT), which abrogates 4-1BB-controlled IDO-mediated immune suppression [47].
The mutation of VHL lysine 171/196 which abrogates its ubiquitin and SUMO modification disabled its function related to inhibition of HIFα transcriptional activity and tube formation.
It is important to note that complete deletion of BACE1 (BACE1−/−), which abrogates Aβ production, can still rescue impaired spontaneous alternation performance concomitant with the prevention of Aβ deposition and neuronal loss in 5XFAD mice at this advanced age [9].
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The emperor retired into Ethiopia to await negotiations, and on October 26 , 1896 he signed the Treaty of Addis Ababa, which abrogated the Treaty of Wichale.
The Somoza regime was deposed in 1979 by a junta, led by the Sandinistas, which abrogated the old constitution and suspended the presidency, Congress, and the courts.
In conclusion, we identified selected mutations which abrogate AP-1 binding to their respective binding site without altering the underlying amino acid sequence of the HIV-1 reverse transcriptase.
This was verified with the Stat6 Y641 mutant (Y641W), which abrogated ubiquitination induced by IL-4.
We also utilized rapamycin, which abrogated S6 phosphorylation, while did not prevent p53 induction by nutlin-3a.
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