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Whether this relies partially or at all on recognition of apo A-I remains to be determined.
The mechanisms by which this is achieved have not yet been elucidated, and it is unclear whether this relies on interactions with histone lysine methylation.
And finally, it is not clear whether viral proteins are directly involved in the methylation of the CpG loci downstream of the CDKN2A gene promoter, or whether this relies on other ancillary proteins.
Indeed, during primordial germ cell specification, there is genome-wide erasure of H3K9me2 as part of a global resetting of the epigenome; however, it remains to be examined whether this relies on histone demethylase activity [ 137– 137].
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We thus evaluated whether GSIXII treatment had an impact on mammosphere formation by breast cancer cell lines and whether this relied on cell-death induction.
Utilizing thought experiments and language in this way, philosophical theology has a stake in the soundness and richness of the imagination, picturing the way things might be "in one's mind's eye," whether or not this relies on any actual imagery.
We next investigated whether endogenous IRE1a inhibits GEP-mediated osteoblast differentiation and whether this inhibition relies on JunB.
Whether this works relies, to a large extent, on the amount the acquirer pays for the brand, as would be expected.
Furthermore, we investigate whether this therapeutic outcome relies on BV's potent antioxidant effect on reactive oxygen species (ROS -mediated signalling.
Because we previously showed that Rod1 is required for an efficient glucose-induced ubiquitylation of Jen1 (Becuwe et al., 2012b), the observation that Jen1 can be partially internalized in the absence of Rod1 led us to investigate whether this endocytosis still relies on Jen1 ubiquitylation.
To test whether this neuroprotective effect relies on BDNF signaling, we injected sterotactically 3.5- to 4-week-old R6/2 mice (or wild-type littermates) with a recombinant adeno-associated viral vector encoding CB1 receptor (or empty vector) into the dorsolateral striatum.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com