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If cluster headache is indeed a chronobiological disorder, an important question is whether the pathology resides in the biological clock itself, or in the adaptation between the clock and the environment.
Whether the pathology is induced by elevated dietary fat content per se or is instead due to a change in dietary fatty acid composition (e.g. elevated n-6∶n-3 ratio) was not addressed by this experimental design.
Unclear is whether the pathology of small fibers is influenced by glycemic control.
It is unclear whether the pathology observed in gld mutant mice is due to the loss of the membrane-bound or the secreted form of FasL or both.
Accordingly, elucidating whether the pathology prompts changes to these complexes could provide valuable information for the design of new PD therapies.
However, future experiments should address whether the pathology can be induced by more practical and relevant routes of exposure to materials not coming from terminally-sick individuals.
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It remains unclear whether the pathologies of MND and HAD overlap or are distinct.
The same test of rank correlation was used to investigate the relationship between the students' grades and whether the students wanted the pathology curriculum to be changed.
The patients with ear discharge were suction cleaned to identify the pathology whether bacterial/fungal and appropriate treatment was given in the form of antibiotic ear drops/antifungal ear drops.
Overexpression of the mutant gene in cells grown in culture alters many of the signaling pathways inside the cells, but it is unclear whether these alterations cause the pathology seen in the disease.
Further studies are needed, however, to assess whether the PPI deficits are limited to the advanced phase of the pathology or whether the R6/1 mouse line does not model this HD-like symptom.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com