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Therefore, we investigated whether further increase of miR-130a level would cooperate with YAP to promote transformation of HMLE cells.
Future studies will show whether this catch-up effect is occurring or whether further increase will appear.
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There is no way of establishing whether further increases in diversity in England would be a net gain or a net cost.
And it left open the possibility of widening the spread further in the future, saying it "will assess over time whether further increases in the spread are appropriate in view of experience" with the new half-point spread.
It is unclear whether further increasing follow up interval to annual would have an effect on detection of local recurrence.
We then explored a potential role for mTORC1 signaling in p53-mutation-mediated tumor formation by investigating whether further increases of mTORC1 activity enhance tumorigenesis.
To determine whether further increases in the number of rate categories yield additional benefits, we also tested models with four (FL4) and five (FL5) rate categories.
It remains to be determined whether further increases in dose intensity could be reached in patients without severe haematoxicity if doses were escalated on an individual basis, in addition to using GM-CSF.
However, it is not clear whether a further increase in VAT will be possible, whether oil revenues could be used to co-fund the NHI or whether other indirect taxes or innovative financing options (e.g. such as levies on large and profitable companies as with the 10% levy on mobile phone companies in Gabon [ 2]) could be explored.
Whether a further increase in ecological validity of the task would be useful, should be tested empirically in future research.
The estimated total SSS volume is compared with the observed total SSS volume to indicate whether a further increase of its total SSS volume is (theoretically) possible for that particular country, based on its number of large SSS ports and GDP per head (Fig. 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com