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Whether destabilization of Yju2 and Cwc25 by Prp16 leads to destabilization of RNA structures, or vice versa, is unclear.
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Based on the results of the immunofluorescence analysis (Figure 6), we examined whether lysosomal destabilization occurs during LAPTM5-induced cell death.
Destabilization, whether in the form of civil wars in which the US took sides based on its political ideology or a US deportation policy that created the very gang problems plaguing countries like El Salvador, has been go-to policy in the US for decades.
This led us to test whether the sole destabilization of the actin network could trigger AdcA phosphorylation.
It therefore remains to be determined whether the observed destabilization of EZH2 upon Ogt knock-down is restricted to particular cell lines in mammals.
We next determined whether the observed destabilization of nonacetylated RASSF5 is due to poly-ubiquitination. Results in Figure 5c suggest that Itchwt but not ItchC830A, induces poly-ubiquitination of eRASSF5 in C646-treated cells, suggesting that acetylation negatively modulates RASSF5 interaction with Itch.
To determine whether or not AER destabilization is the primary factor driving cleft formation, we examined the AER of A. uniparens in order to first understand how a 'typical' AER is structured in pentadactyl lizard autopodia (Fig. 3).
We next investigated whether the p.Y329S-associated protein destabilization could be 'rescued' by pharmacological chaperone treatment (28).
The magnitude of oxidative stress determines the degree of lysosomal destabilization and, consequently, whether arrested growth, reparative autophagy, apoptosis, or necrosis will follow.
We were also interested whether MLC1 mutations would lead to destabilization of the complex with reduced or altered expression of DGC-members in MLC brain.
Given that breast metastasis suppressor 1 (BRMS1) was described as an E3 ubiquitin ligase for p300, we tested whether BRMS1 was responsible for p300/CBP destabilization in iASPP-depleted cells.
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