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Whether attaining higher levels in the range of 90 100 nmol l−1 would reduce incidence remains unclear.

Whether attaining considerably higher levels would provide further benefits on cancer currently cannot be addressed adequately based on the available RCT data.

It was therefore the purpose of the present study to investigate whether attaining a state of remission conveys a benefit when compared with low disease activity from a patient perspective, as well as from a socioeconomic point of view, by using a population of routine clinic patients.

Graduation outcomes depend on whether students attain or exceed minimum grade and credit hour requirements both overall and within their chosen major field.

Measures of whether patients attained clinical performance targets at 6 months after enrollment in the study served as the independent variables for this study.

We first compared patient characteristics by whether patients attained individual targets and by the total number of targets they attained using Pearson's χ2 tests for categorical variables and two-sided t tests or ANOVA for continuous variables.

Primary efficacy analysis was noncomparative, testing whether masitinib attained a median progression-free survival (PFS) (blind centrally reviewed RECIST) threshold of >3 months according to the lower bound of the 90% unilateral confidence interval (CI).

Observed survival time was assessed starting at time of patient enrollment and ending at death or censoring (at transplant, loss to follow-up, or closeout), and we assessed individual cumulative mortality by whether patients attained targets by calculating overall crude mortality rates at the average follow-up (2.8 years) and by using Kaplan-Meier methods.

A common approach is the landmark analysis, whereby a particular threshold (e.g., BCR-ABL1 ratio ≤ 0.1% on the international scale [IS]) and time (e.g., 3 months) are chosen, and longer-term outcomes (e.g., progression-free survival or event-free survival [EFS] at 2 years) are evaluated according to whether patients attained the threshold at the landmark time point [ 18- 23].

After 5 years on ART, expected age at death was 50 (38 63), 72 (64 79) and 75 (70 81) years depending on whether their attained CD4+ cell count was less than 200, 200 349 or at least 350 cells/μl, respectively (supplementary table 7).

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