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This microRNA has been described as a tumour suppressor gene in different tumour types (Song and Bu, 2009; Wu et al, 2009; Majid et al, 2011), a reason whereby we decided to further study its role in lung cancer.
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We decided on a design whereby new clients would be randomised to either receive immediate counselling or be on a wait list for three months.
On the basis that it was still of value to monitor the potential effects of implementation of the NHS Health Check programme and to estimate the value of additional lifestyle support, we decided to proceed with a modified trial whereby patients were randomised to groups within practices, accepting the potential losses of attribution to treatment and to statistical power that this would entail.
"During that trial, we experienced an issue whereby a greater number of transactions were being flagged for further checks than necessary, so we decided to pause the trial until this could be rectified.
Since the amount of food taken over 4 hrs by single animals was close to the limit of detection, we decided to rely on mean food amounts taken per cage (i.e., per 3 mice), whereby each treatment group consisted of n = 6 cages.
We decided to be conservative with these few cases because of the possible uncertainty in the mapping data, whereby markers (and the inferred linked QTLs) could be erroneously mapped at distant locations.
We decided?
We decided to charge.
We decided to marry.
We decided to run".
We decided to experiment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com