We hypothesize that the unilateral rupture enhanced ground shaking north of Mt. Kinabalu and whereby triggered relatively extensive small landslides north of the mainshock epicenter and few to the south.
Endotoxins are important in the pathogenesis of septic shock, whereby infection triggers a systemic inflammatory response, resulting in release of pro- and anti-inflammatory cytokines [4 6] (Fig. 1).
The formation of the proper number of tip-cells is regulated by delta-like ligand 4/(dll4)/Notch receptor signaling, which forms a lateral inhibitory circuitry, whereby VEGF triggers expression of dll4, which in turn inhibits the VEGF responsiveness, and hence the induction of the tip-cell phenotype in neighboring endothelial cells [2], [3], [4], [5], [6].
The present results suggest a mechanism whereby celastrol triggers the accumulation of polyubiquitinated protein aggregates by disrupting sulfhydryl homeostasis and exerting widespread proteotoxicity in glioblastoma cells, as summarized in Figure 6.
Co-release of all the three by CHGA from endothelial cells was consistent with a mechanism whereby CHGA triggered exocytosis of the endothelial cell secretory granule: the Weibel Palade Body.
The results of this study, for the first time, support a model whereby RSV triggers AMPK-PGC-1 α signaling, which is required for ERR α-dependent Sirt3 transcription and subsequent enrichment within the mitochondria.
A study performed on insulin-resistant rats has uncovered the involvement of a gut brain liver axis whereby metformin triggers a duodenal AMPK-glucagon-like peptide-1 receptor-PKA-dependent neuronal signalling pathway to reduce hepatic glucose production [ 44].
This pattern is consistent with a biased discovery process which exhibits properties of reinforcement, whereby commonly studied proteins are more likely to be further studied in the near future, and with triggering, whereby discoveries spur related discoveries in the PPI network neighborhood.
The model features "reinforcement", rich-get-richer type dynamics with "triggering" whereby novel discoveries trigger the possibility for a subset of new discoveries.
