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These results confirmed the important role of iPLA2γ, whereby decreasing iPLA2γ activity aggravates mitochondrial degeneration to induce neurodegenerative disorders in a rotenone rat model of Parkinson's disease.
Moreover, therapeutic delivery of these miR-29 mimics during bleomycin-induced pulmonary fibrosis restores endogenous miR-29 function whereby decreasing collagen expression and blocking and reversing pulmonary fibrosis.
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Here, a novel hypothesis is proposed whereby decreased Reelin expression in the mature brain causes destabilization of neurons and their processes, leading to aberrant plasticity and aberrant wiring of brain circuitry.
Therefore a similar mechanism to this could be responsible for the effect of the -61C allele, whereby decreased Hp concentrations causes increased oxidant stress, increased levels of senescent/damaged red cells and therefore increased red cell turnover and perhaps increased phagocytosis of infected red cells.
Our genetic studies support various biochemical and tissue culture models whereby decreases in capulet function lead to increased actin in small aggregates, while over-expressed Cofilin in a capulet mutant background leads to larger accumulation in actin rod-like structures.
Also IRI-EC was a significant predictor, whereby velocity decreased with higher IRI-EC scores, that is, the velocity drop increased (β = −0.38, t = 2.7, p<0.05; Figure 3A, Table 1).
Overall, female gender was associated with lower costs, whereby costs decreased with increasing age.
Results showed that the BZD and antidepressant combination had a significant impact on patient behaviour whereby it decreased dropout rates.
We propose a mechanism whereby MUC5B decreases surface tension lowering capacity of alveolar surfactant at areas with maximal mechanical stress.
Other evidence suggests a mechanism whereby fructose decreases TG clearance by lipoprotein lipase, due to decreased glucose-stimulated insulin secretion and increased chylomicron remnants (31).
However, a main effect for time was observed whereby SI decreased postprandially in both supplements (pooled placebo and drug data, p < 0.05).
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