Stochastic resonance (SR) [1] is a nonlinear phenomenon whereby the addition of noise can improve the detection of weak stimuli.
Stochastic resonance is a nonlinear phenomenon whereby the addition of noise can improve the detection of weak stimuli.
In relation with this, stochastic resonance, which has been studied extensively in the context of sensory system [40], in its most general form can be said as a process whereby the addition of random function or 'noise' can optimize a physical or biological process.
Significantly, inhibition of quorum sensing reduces pathogenicity of bacteria and impedes formation of antibiotic-resistant biofilms, and therefore offers an attractive mechanism whereby the addition of a macrolide could reduce mortality in CAP [ 6].
We have recently reported an alternative fluorophore generating reaction, whereby the addition of two equivalents of an alkyl thiol to 2,3-dibromomaleimide (DBM) generates the dithiomaleimide (DTM) fluorophore (Scheme 1).
QCM-D can be considered to be a nano-sensitive weighing device whereby the addition of mass to the surface of the chip leads to a change in the frequency (f) which is directly proportional to the mass [ 19].
Previous research has shown the role amino acids play in mTOR activation in mammalian cells (Hara et al, 1998), as well as the involvement of amino acids in the regulation of the mTOR pathway, whereby the addition of amino acids inhibited autophagy and increased S6 phosphorylation in rat hepatocytes (Blommaart et al, 1995).
In other studies Scheibner (2006) and Hülsdau (2007) showed that the oxidation of β-carotene by the purified DyP-type peroxidase MsP1 from culture supernatant can take place without addition of H2O2, whereby the enzyme activity was increased by addition of H2O2.
The addition of ALAN, whereby light of a different spectrum and intensity to natural light is present during naturally dark phases, has been demonstrated to affect metabolism [ 2, 3], behaviour [ 4] and circadian clock regulation [ 5– 8] in numerous organisms.
