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Whereas, gain of function mutations in Tm increase Tm flexibility lowering the energy required for Tm movement and making the thin filament more readily activated [31], [61].
Whereas, gain of function mutations of LRP5 have been shown to lead to disorders of increased bone mass such as sclerostosis [ 19], Van Buchem's disease [ 20], osteopetrosis [ 9] and endosteal hyperostosis [ 10].
Whereas gain control is involved in motion deficits (e.g., 33), processing of motion also clearly involves integration, because motion is signaled by direction-sensitive cells in V1 whose responses are then pooled by MT neurons with larger receptive fields to signal complex motion.
Body weight and average daily gain were similar among treatments, whereas gain:feed linearly increased across treatments, with a tendency for a treatment by time interaction.
Linearized versions of the model are analyzed and show large variations in system gains at steady state as function of load whereas gain variations near the desired bandwidth are small.
Gain of 17q has been associated with longer disease-free survival and low risk of developing distant metastasis [9], whereas gain of 7q32 has been associated with poor prognosis [5].
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In our study, loss-of-function assay using MCF-7 cells transfected with JAM-A siRNA showed that knockdown of JAM-A promotes the migration of breast cancer cells, whereas gain-of-function assay by overexpressing JAM-A in MDA-MB-231 cells showed that JAM-A overexpression attenuates migration.
So whereas gaining money is important, gaining an investor with specific expertise, for example the marketing of high-tech products, is equally valuable, notes Smith.
–The gains in a nonqualified variable annuity are subject to ordinary income tax rates when withdrawn, whereas gains in a retail mutual fund held in a taxable account qualify for the more favorable long-term capital gains tax treatment, as long as the fund was held for more than one year.
Deletions have a median length of 44.2 Kb and cover an average of 33.3 Mb per strain (1.3%), whereas gains have a median length of 53.2 Kb and cover only 13.8 Mb per strain (0.54%) (Table 2).
MBNL1 loss-of-function in these cells results in mTOR signaling alterations, whereas gain-of-function experiments rescue the phenotype (Denis et al., 2013).
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