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Whereas eliminating the ultimate causal agent is not always simple, knowing the immediate mechanism allows for interference with the abnormal, cancer-causing function, in turn facilitating the development of highly effective anticancer drugs.
Thus, in all cases, making a class of input neurons nonresponsive inhibited the hub and other spokes, whereas eliminating the same neurons did not.
Hatem et al. [ 3] suggest that the JH-controlled mechanism favors large body size, but at the cost of more prolonged development, whereas eliminating the repression of ecdysone secretion by JH favors rapid development time.
Usually plant-breeding data is collected for single plants, situated in a field or greenhouse, with a predetermined experimental design of planting pattern to enable statistical analysis whereas eliminating potential interfering factors, such as location in the field.
They show that light-mediated stimulation of those neurons entrains the respiratory rhythm whereas eliminating the expression of both transcription factors or reducing their synaptic transmission abolishes the respiratory chemoreflex.
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Eliminating the sorption of phosphate species onto As-2LFh provided only a slight increase in the sorbed As III) fraction (about 65% at pH 6.3), whereas by eliminating the sorption of carbonate species onto 2LFh resulted in a strong increase (about 95% at pH 6.3).
Whereas, AHP consistently eliminated detectable viability in all TBF and BBF formed under low nutrient conditions.
Concomitantly, IR-induced liver mRNA and protein expression of NLRP3 and interleukin-1β (IL-1β) were restrained by T3, whereas CC eliminated T3-dependent PC.
Lanes 3 and 5 included all 12 species-specific PCR primer sets, whereas we eliminated mouse primer pairs in lanes 2 and 4. We used the mouse-free PCR primer sets because they would not compete with the human primer pair if the human genes were present in very low copy levels.
Consistent with this, addition of (dT 8 had no discernible effect on the binding of GST-α1 to Rpa70N, whereas it eliminated the binding of GST-OB to Rpa70AB in a manner dependent on the stoichiometry of (dT 8 to Rpa70AB.
While we also observed embryonic lethality around E7, the ratio of pups born for the +/+, +/− and −/− genotype was 25∶55∶0 for our model eliminating exon 2, whereas the model disrupting exon 3 [34] reported a ratio of 414∶515∶0.
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