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In AMC-HN9 cells with wild-type p53 (wtp53), 17AAG significantly increased p53 levels, whereas dramatically decreasing the level of MDMX in a concentration-dependent manner, beginning 4 h after treatment.
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It can be seen from Fig. 3 that the EENS basically remains unchanged after the ratio is larger than 1.38, whereas it dramatically jumps when the ratio is smaller than 1.38.
Thus, a frequency increase virtually does not influence the fatigue life of C/PPS laminates, whereas it dramatically decreases the fatigue life of Epoxy-based laminates (−100%), because of a more extensive damage and a faster damage growth.
Similarly, in the CDDP group an effective urine volume output was maintained whereas it dramatically dropped in the THD patients.
CLL cells cultured alone underwent progressive and time-dependent apoptosis, as previously reported, whereas MSCs dramatically increased the survival of CLL cells, as previously shown.
As shown in Figure 3C, treatment with 10 μM Cd resulted in robust activation of p44/42 MAPK as indicated by intense red positive signals in ht-UtLM cells and ht-UtSMCs, whereas PD dramatically inhibited phospho-p44/42 phospho-p44/42n.
MMP-14 expresses at a low level in primary colon cancer cells, whereas expression dramatically increases in colon cancer cells located at the invasive front, or those that have already invaded into the submucosa.
In activated TEM (effector memory) cells Kv1.3 is selectively upregulated (highKv1.3 : lowKCa3.1 phenotype); on the contrary, in TCM (central memory) cells, Kv1.3 only modestly upregulated, whereas KCa3.1 dramatically (by 1.5 order of magnitude increase), producing lowKv1.3 : highKCa3.1 phenotype [ 151– 151].
Interestingly, the trifluoromethyl substitution of GSK317354A and the naphthyl substitution of GSK270822A increase potency of ROCK inhibition by 10- and 5-fold, respectively, whereas they dramatically reduced GRK inhibition (Table 2).
Direct violence injures or kills people quickly and dramatically, whereas structural violence is much more widespread and kills far more people by depriving them of satisfaction of their basic needs.
The undercutting in pure KOH is significantly high, whereas it is dramatically suppressed in alcohol-added solutions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com