It is recruited to phosphorylated EGFR through its SH2 domains, where it serves as a substrate for EGFR kinase activity.
Phosphorylation of E-cadherin promotes internalization, whereas phosphorylation of β-catenin decreases its affinity for E-cadherin, allowing nuclear localization where it serves as a transcriptional co-activator of TCF/Lef1 factors [ 22, 23].
But it is an effective device in Beattie's short stories, where it serves as a kind of flypaper.
It is involved in high-precision DNA transactions where it serves as a key architectural component of specialized nucleoprotein structures (snups).
The oyster has been embraced by community groups in the Bronx, where it serves as a positive counterpoint to the much-publicized pollution of the river.
The RNA travels to the cell's protein factory, where it serves as a template for cranking out specialized proteins based on the genetic code.
In addition, PKM2 can translocate to the nucleus, where it serves as a transcriptional co-activator to induce HIF1α-dependent glycolytic gene expression24.
Results: Office paper dipped in carbon-nanotube ink becomes a strong, flexible, highly conductive material that can be incorporated into lightweight batteries (where it serves as a conductive layer) or high-energy capacitors called ultracapacitors (where it serves as an electrode).
In a gesture that recalls the Metropolitan Opera's production from the 1950s, the overture is positioned after the first act, where it serves as a bridge between relative order and the turbulence to come.
The elevated slab overhangs a portion of the old building as well as the former parking lot, where it serves as the roof over a new outdoor piazza for the school.
It is one of antiquity's essential parables of betrayal, a warrior's fantasy turned nightmare, dramatized by Aeschylus (here in Robert Fagles's translation) and found much earlier in Homer's "Odyssey," where it serves as a warning to Odysseus: Don't go home.
