Finally, Tip60-p400 may recruit Hdac6 to its target genes, where it regulates gene expression by deacetylating histones.
This allows NF- κB to translocate to the nucleus where it regulates the expression of its target genes.
Adiponectin is secreted exclusively from adipocytes into the bloodstream where it regulates a number of metabolic processes including glucose regulation and fatty acid catabolism [ 19, 20].
As Americans know all too well, Congress has greatly expanded its reach far beyond these powers to the point where it regulates nearly every aspect of our lives.
It resides in the nucleus, where it regulates cell proliferation and cell death.
The Hedgehog-GLI (HH-GLI) signaling is of critical importance during embryonic development, where it regulates a number of cellular processes, including patterning, proliferation and differentiation.
TGFβ superfamily member Activin-A is a multifunctional hormone/cytokine expressed in multiple tissues and cells, where it regulates cellular differentiation, proliferation, inflammation and tissue architecture.
FFA1 is expressed in pancreatic β-cells, where it regulates glucose-dependent insulin secretion, and GPR120 has been implicated in mediating GLP-1 secretion.
CL is mainly found in the inner mitochondrial membrane where it regulates mitochondrial function.
Following this cleavage, the Notch intracellular domain (NICD) translocates to the nucleus where it regulates gene expression [47], [48].
In mice, E-cadherin is also expressed in neural stem cells, where it regulates self renewal [26].
