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P-glycoprotein (P-gp) is an ATP-dependent 170- to 180-kDa transmembrane glycoprotein present at the luminal side of the BBB where it prevents its substrates from entering the brain.
This saturation reaches a threshold where it prevents further brain processing, and so, you then experience 'burnout'burnout
The first time it happens, it's really, really freaky because there's no other point in the game where it prevents you from moving like that".
The X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in several malignant cells where it prevents apoptosis by binding to, and blocking, the activation of caspase-3, -7, and -9.
IpaD [Ipa (invasion plasmid antigen)] is the first protein to localize to the T3SA needle tip, where it prevents premature effector secretion and serves as an environmental sensor for triggering recruitment of the translocator protein IpaB to the needle tip.
CMTM6 is not required for PD-L1 maturation but co-localizes with PD-L1 at the plasma membrane and in recycling endosomes, where it prevents PD-L1 from being targeted for lysosome-mediated degradation.
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These agencies cited numerous examples where it prevented the use of deadly force in many situations, thereby saving lives.
The therapeutic potential of the Apaf-1 inhibitor was confirmed in vivo, where it prevented mesothelial cell loss induced by either TNFα/IFNγ or by bacterial peritonitis.
We have already demonstrated an antioxidant function of TAT-administered α-syn in rat PC12 cells, where it prevented H2O2 oxidative damage by raising the HSP70 protein level [36].
Of the three TRPML members, TRPML1 is widely expressed and has been described as an H+-sensor of endosomes/lysosomes, where it probably prevents overacidification [11].
Our finding that the NKG2A receptor is capable of modulating TH2 cell effector function is analogous to its purpose on CD8+ cytotoxic T cells, where it helps prevent cytotoxicity of HLA-E expressing cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com