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Rather, our results suggest that the recovered DPE/MTE/PB motif is more frequently found by chance (outside its location where it is functional) as compared to the other motifs.
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Like relationships, I think a lot of bands go many, many years past where it is working in a functional way.
The farnesylated form of p53 resided mainly in the cytosol, where it is non-functional.
Note that all motifs are found with the highest frequency at the expected location but that the DPE/MTE/PB is less specific and more frequently found at positions where it is unlikely to be functional.
This type of 'guilt-by-association' analysis is frequently employed in functional genomics, where it is used to assign putative functions to genes and interaction partners to proteins [42].
The purple tetrahedrons show areas where it is best to avoid bulkier functional groups.
One conclusion often drawn from this disparity is that a large proportion of TF binding events may be "opportunistic" rather than "functional," where it is thought that TFs bind to regions that happen to be accessible and contain relevant motifs, without this binding being particularly relevant in terms of transcriptional control processes.
Upon experiencing stress the 90 kDa ATF6 protein translocates from the ER to the Golgi where it is proteolytically processed to a functional 50 kDa transcription factor that binds to specific ER stress elements and directs the synthesis of chaperone proteins that mitigate protein misfolding through various mechanisms [ 18, 19].
For the older generation, food has become "exciting where it was once functional".
And by doing this, they completely bring a site down to where it's not functional". Upset site owners contacted Cuil to see why Twiceler was hitting sites so often.
And by doing this, they completely bring a site down to where it's not functional".
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CEO of Professional Science Editing for Scientists @ prosciediting.com