Stabilization of β-catenin allows its nuclear translocation, where it functions as a transcriptional co-activator along with the T-cell factor (TCF) and lymphoid enhancer factors (LEF) (Behrens et al., 1996; Molenaar et al., 1996).
YAP phosphorylation leads to its interaction with 14-3-3 14-3-3 14-3-3es its loss from the nucleus which it functions as a coactivator of promotes
The nuclear response is much slower, as the ER-estrogen complex moves to the nucleus, where it functions as a transcription factor, both activating and repressing gene expression.
HuffPo, as it is known, is a mighty force in America, where it functions as a combination of news ticker and liberal talking-shop.
(a) The ΔF508 variant of CFTR is characterized by ER accumulation, misfolding and an inability to traffic correctly to the plasma membrane where it functions as a chloride channel.
Gaming is reaching a new audience in the business world, where it functions as a superb training and operations tool.
Figure 1a shows the introduction of perovskite material in DSSC where it functions as a replacement for the dye sensitizer for the mesoporous TiO2 layer.
Etcd, which is written in Go, is already a major component of many Kubernetes deployments, where it functions as a source of truth for coordinating clusters and managing the state of the system.
In addition, AP-2 recruits clathrin onto the membrane, where it functions as a scaffold for vesicle budding.
The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase.
For example, the capsaicin receptor, TRPV1, is expressed by primary afferent somatosensory neurons, where it functions as a detector of noxious heat [5].
