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An inverse correlation between WMSI and CFR was found in our SSc patients, similar to other pathological conditions where microvascular dysfunction is present, such as after reperfusion in acute myocardial infarction [ 40] and dilated cardiomyopathy [ 41].
In our study, we observed a strong correlation profile between evaluated DNA samples in patients with DC, where heritable telomere dysfunction is present, particularly between blood and buccal cells (r=0.90) and buccal cells and fibroblasts (r=0.90).
The cognitive dysfunction is present in the interictal phase and during migraine attacks [8].
It is unknown whether a neuroepithelial dysfunction is present.
Cardiac dysfunction was present in 23 patients (38%) with brain death.
As selected by the inclusion criteria, in the control group none of the patients presented with severe diastolic dysfunction, but in 5/11 (45%) moderate diastolic dysfunction was present.
Surgical decompression was indicated if signs of organ dysfunction were present.
Right ventricular dysfunction was present in 214 (55%) of 388 patients who met the inclusion criteria isolated right ventricular dysfunction was seen in 100 (47%) and combined right and left ventricular dysfunction in 114 (53%).
Coagulation dysfunction or platelet dysfunction were present in five patients.
No bowel or bladder dysfunction was present.
Thyroid dysfunction, loss of libido, and erectile dysfunction are present in a large proportion of patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com