The number of evoked spikes as a function of injected current was fitted with a curve: n s (i ) = m a x (0, e x p (- (i - a ) / b ) - e x p (- (i - a ) / c ) ) · d where i is current, and a-d are fit parameters.
with, where is the electrical potential across a neuron's membrane,, are the gating variables associated with the activation and inactivation of ion currents, respectively, is the gating variable associated with the activation of ions current and where I represents current injected through the cell membrane.
Concentration dose response curves were fit to an equation of the form: I / I MAX = A m p 1 + (K D [ C a ] ) H where I denotes current, IMAX is the maximum current elicited by the highest concentration of divalent cation, Amp is the maximum value of I/IMAX at a given voltage, K D is the apparent dissociation constant, and H is the Hill coefficient.
As previously dose-response data were fit with the Hill equation where I represented current at concentration A of agonist and Imax was the maximum current and n represented the Hill coefficient [77].
where I is current (A), V is voltage (V), E → is electric field intensity (V m), J → is current density (A m2), a is a surface enclosing the source electrode, l is the path length for potential calculation, and σ is the blood conductivity (the reciprocal of blood resistivity ρ).
The capacitance was calculated by the equation: C = 2I · t d /[(U m -ΔU) · m], where I is current of charge/discharge, t d is a time of discharge, U m is a maximum voltage, ΔU is a voltages drop of short circuit of discharge circuit, m is a weigh.
The capacitance was calculated by the equation C = 2I · t d / [(U m−ΔU) · m], where I is current of charge/discharge, t d is time of discharge, U m is maximum voltage, ΔU is voltage drop of short circuit of discharge circuit, and m is weight.
Current-voltage-relationships were fit with the following equation: I = V − E r e v { 1 + exp (V − V 1 2 R T / F ) where I is current and Erev is the extrapolated reversal potential.
Each transduction function is represented by Equation 1, where I is current, ε; is SED, β is an offset, M is the number of Merkel cell neurite complexes in the cluster, and α and λ are gains for SED and the first derivative of SED, respectively.
1-I/Imax represents the normalized current where I is the residual current measured in the presence of 1 mM cGMP after the application of M-2-M and isax is the cGMP activated current at the beginning of the experiment.
