Exact(35)
On a functional level, 5-Fluorouracil induced slight upregulation of Caspase-8 and sensitized cells towards TRAIL-induced apoptosis when TRAIL was applied in high concentrations.
Second, the metabolic effects of TRAIL should be taken into account when TRAIL agonists are applied for the treatment of cancer.
However, the selectivity of TRAIL for tumor cells over normal cells is lost when TRAIL forms multimeric complexes.
Significantly this occurred when TRAIL was co-injected with cells that had previously not been subjected to TRAIL while in cell culture.
Interdependently, scheduled treatment of the cultures with TG followed by subsequent addition of TRAIL resulted in a significant synergistic apoptotic activity, while in contrast, no obvious augmentation was seen when TRAIL was added before TG.
Thus, many tumors resistant to TRAIL-mediated apoptosis when TRAIL is used as a single agent will respond to a combination of conventional chemotherapy or radiotherapy plus TRAIL [ 5, 32, 33].
Similar(24)
They are 0-4 when trailing at halftime.
The Red Bulls are now 0-7 when trailing at halftime.
The Rangers are 2-6-1 when trafterg aftwo two periods.
The Flyers were 0-8-3 when trafterg aftwo two.
The Stars are 1-11 when trailing after two periods.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com